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SEROQUEL use was associated with mean increase in heart rate, assessed by ECG, of beats per minute compared to mean increase of beat per minute among placebo patients. Pharmacokinetics Quetiapine fumarate activity is primarily due to the parent drug. Patients with these diagnoses were excluded from premarketing clinical studies. It is not known whether Seroquel appears in breast milk, and breastfeeding is not recommended. It is generally believed though not established in controlled trials quetiapine nosutiti pa nakti that treating such an episode with an antidepressant alone may increase the likelihood of precipitation of mixed manic episode in patients at risk for bipolar disorder. The majority of patients in these trials taking SEROQUEL were dosed in range between 400 and 800 mg per day. Subsequently she was successfully managed with ECTs, and quetiapine 600mg and risperidone 6mg daily.