Coli bacterial tests but was observed to be potential clastogen in in vitro assays CHO K1 and CCL 61 Chinese hamster ovary cells. The most common side effects seen with Femara include hot flashes, joint femara fedex senza prescrizione pain, night sweats, weight gain, nausea, tiredness, other heart-related events and bone fractures. Other less common side effects may include: constipation, vaginal dryness, trouble sleeping, swelling. In the extended adjuvant setting, the optimal treatment duration with Femara is not known. Ingle says the actual reduction in breast cancer recurrence risk offered by Femara will vary greatly, depending on each woman risk factors, such as the size and aggressiveness of the primary tumor.